Diagnostic Studies
Electrodiagnostic Studies
Recommended to confirm clinical suspicion of ulnar nerve entrapment at the wrist. Electrodiagnostic studies should be conducted by well-trained electrodiagnosticians, preferably certified by the American Board of Electrodiagnostic Medicine.
MRI or Ultrasound
Not recommended for diagnosing ulnar nerve entrapment at the wrist. However, recommended for suspected soft-tissue masses, with MRI being preferable for conditions like ganglion cysts.
CT
Recommended to diagnose ulnar nerve entrapment at the wrist if a hook of the hamate fracture is suspected. CT is preferable for evaluating fractures.
Medications
For most patients, ibuprofen, naproxen, or other older generation NSAIDs are recommended as first-line medications. Acetaminophen may be an alternative for those not suitable for NSAIDs, though NSAIDs are generally more effective.
Non-Steroidal Anti-inflammatory Drugs (NSAIDs) for Ulnar Nerve Compression
Recommended for acute, subacute, or chronic ulnar nerve compression at the wrist. Over-the-counter agents are suggested first. Use should be as needed and discontinued upon symptom resolution, lack of efficacy, or development of adverse effects.
NSAIDs for Patients at High Risk of Gastrointestinal Bleeding
Recommended for concomitant use with cytoprotective drugs for patients at high risk of gastrointestinal bleeding. Consideration is especially important for at-risk patients like those with a history of prior gastrointestinal bleeding, elderly individuals, diabetics, and smokers.
NSAIDs for Patients at Risk for Cardiovascular Adverse Effects
Patients with cardiovascular disease or risk factors should discuss the risks and benefits of NSAID therapy. Acetaminophen or aspirin is recommended as the first-line therapy. If NSAIDs are needed, non-selective ones are preferred over COX-2 specific drugs. To minimize counteraction with aspirin, NSAIDs should be taken at least 30 minutes after or 8 hours before daily aspirin.
Acetaminophen for Ulnar Nerve Compression Pain
Recommended for pain associated with ulnar nerve compression at the wrist, particularly for patients with NSAID contraindications. Usage should be per manufacturer’s recommendations, and hepatic toxicity risks should be considered.
Opioids
Not recommended for acute, subacute, or chronic ulnar nerve entrapment. However, recommended for limited use (not exceeding seven days) for postoperative pain management, especially nocturnally, as an adjunct to more effective treatments.
Glucocorticosteroids – Oral and/or Injected
Not recommended for the treatment of acute, subacute, or chronic ulnar nerve compression at the wrist.